Liquisolid technique is a novel and promising approach to improve dissolution properties of water insoluble drugs. In this technique, liquid medications i.e. liquid drug, drug solution or suspension present in suitable nonvolatile solvent are converted into free-flowing and compressible powder by physical blending with a selected solid carrier and coating material. It has been theoretically believed that such systems exhibit enhanced release profiles due to the increased wetting properties and surface of drug available for dissolution. This technique is used to formulate water-insoluble drugs into rapid or sustained release solid dosage forms. This review shade light on the delivery of various water insoluble drugs by enhancing the solubility. The basic concept, mechanism of solubility enhancement, characterization and application of liquisolid compact.
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